Basic Synthroid Information

• International Nonproprietary Name (INN): Levothyroxine sodium
• Brand names available in Canada: Synthroid, Eltroxin
• ATC Code: H03AA01
• Forms & dosages: Tablets of various strengths
• Manufacturers in Canada: AbbVie, Mylan, Pfizer
• Registration status in Canada: Prescription only (Rx)
• OTC / Rx classification: Rx

Everyday Use & Best Practices

When it comes to taking Synthroid, timing can make a significant difference. Generally, Canadian patients tend to prefer morning dosing. This preference aligns well with the natural rhythms of daily metabolism. By taking Synthroid in the morning, individuals may find it easier to integrate this medication into their routine, which often includes busy mornings that suit medication management. A consistent routine helps to ensure reliable medication adherence, especially in a country where daily life can be quite dynamic.

Taking With Or Without Meals (Canadian Diet Context)

For optimal absorption of Synthroid, it’s crucial to take the medication on an empty stomach. This means waiting at least 30 to 60 minutes before breakfast. Many Canadians start their day with hearty breakfasts—think toast, cereals, or smoothies—which can affect Synthroid’s effectiveness if taken concurrently. It’s essential to be mindful of dietary habits that include common foods like dairy and high-fibre items, as these can impede the absorption of the medication. Maintaining a gap between medication intake and meals ensures that the body can fully utilize the hormone for thyroid function.

Safety Priorities

Understanding safety priorities when taking Synthroid (levothyroxine) can prevent serious health complications. It's essential for patients to be informed about who should avoid this medication and which activities may pose risks during treatment.

Who should avoid it (Health Canada advisories)

Health Canada's guidelines provide clear indications for those who should steer clear of Synthroid. Absolute contraindications include:

• Untreated thyrotoxicosis
• Untreated adrenal insufficiency
• Acute myocardial infarction
• Hypersensitivity to levothyroxine or tablet excipients

Relative contraindications exist as well. Patients with diabetes mellitus may experience altered glycemic control. Those with pre-existing cardiovascular conditions like angina and coronary artery disease must be monitored closely, especially the elderly due to their heightened risk of cardiac complications. Additionally, people suffering from osteoporosis should be cautious as high doses over time can exacerbate bone loss. For anyone who has recently undergone major surgery or is facing acute illness, close monitoring during Synthroid treatment is vital.

Activities to limit (driving, workplace safety)

Side effects from Synthroid can significantly affect daily activities. Common reactions include dizziness, palpitations, and even anxiety, which can hinder focus and coordination. Therefore, caution should be exercised when engaging in activities that require full attention, such as:

• Driving
• Operating heavy machinery
• Any work requiring intense concentration

Being aware of how Synthroid interacts with daily routines can prevent accidents and ensure safety. It's crucial to stay attuned to how the medication affects personal well-being and adjust activities accordingly.

Dosage & Adjustments

General regimen (DIN references)

Understanding the proper dosage of Synthroid (Levothyroxine sodium) is crucial for effective management of hypothyroidism.

For most adults, initial doses typically range between 25–50 mcg taken once daily. This can be adjusted every 4–6 weeks based on TSH levels, moving towards a full replacement dose of approximately 1.6 mcg/kg/day.

Commonly referenced Canadian Drug Identification Numbers (DIN) include:

• Synthroid: DIN 00303467
• Eltroxin: DIN 00007281

Close monitoring of TSH levels is necessary to determine the right dosage adjustments, ensuring the patient remains within the therapeutic range without crossing into hyperthyroidism.

Special cases (elderly, comorbidities)

For the elderly, the approach entails starting with lower doses, typically between 12.5–25 mcg/day, due to their enhanced cardiovascular sensitivity. Individual factors, including age and additional health issues, can necessitate more cautious increases.

Children often start at lower doses as well, usually around 10–15 mcg/kg/day for neonates suffering from severe hypothyroidism.

In patients with comorbidities, particularly those with heart disease, careful dosage is vital. Such patients should be monitored closely, as they may experience more pronounced side effects or interactions with other medications, necessitating tailored adjustments to their Synthroid regimen.