Basic Uniphyl CR Information

• INN (International Nonproprietary Name): Theophylline
• Brand Names Available in Canada: Uniphyl, Theolair, Elixophyllin
• ATC Code: R03DA04
• Forms & Dosages: Extended-release tablets (100 mg, 200 mg, 250 mg, 300 mg, 400 mg, 450 mg, 600 mg); Oral solution (80 mg/15 mL)
• Manufacturers in Canada: Medicis and several generic pharmaceutical companies
• Registration Status in Canada: Approved for prescription use, mainly for asthma and COPD
• OTC/Rx Classification: Prescription only

Everyday Use & Best Practices

When considering Uniphyl CR, flexibility in dosing schedules often suits Canadian lifestyles. The general recommendation is a once-daily dosage, allowing patients to choose a time that best fits their routine, whether it’s in the morning or evening. This can greatly impact adherence to medication, as individuals can align their dosing with other daily habits.

In terms of meals, taking Uniphyl CR can be adjusted according to personal preference, though it's typically advised to be taken consistently with respect to meals. In a typical Canadian diet, balancing between rich foods and lighter options may affect absorption. Therefore, those frequently enjoying heavy meals might consider leaving a gap of at least a couple of hours between eating and taking their medication.

Safety Priorities

It's crucial to be aware of specific groups who should avoid Uniphyl CR, according to Health Canada advisories. Patients with a known allergy to theophylline or previous severe reactions to xanthines should refrain from use. Additionally, those recovering from recent acute myocardial infarction, those with poorly controlled seizure disorders, or active peptic ulcer disease may be advised against this medication.

Caution is warranted regarding activities that may be affected by the medication's side effects. For instance, operating a vehicle or machinery could pose risks if the patient experiences dizziness or insomnia, common effects of Uniphyl CR. In Canadian workplaces, maintaining safety relies on being alert and properly aware of one’s environment. This could mean adjusting work schedules or discussing medication use with employers to ensure safe practices.

Dosage & Adjustments

The standard dosage regimen for Uniphyl CR varies between adults and children, typically ranging from 300 mg to 600 mg daily as an extended-release form. According to Health Canada, dosing can be individualized based on patient response. For adults, common regimens include either a single dose of 400 mg or as divided doses depending on the specific case.

In special cases like elderly patients or those with comorbidities, careful consideration of dosage is essential. Older adults may require starting at lower doses—monitoring for efficacy and adverse effects is critical, given their increased sensitivity. Children are generally given doses based on weight, starting at around 10-13 mg/kg/day. This monitoring ensures that potential toxicities can be managed quickly, reinforcing the need for regular check-ups and possibly more frequent blood level assessments.

Similarly, patients with liver or renal impairments may need dosage adjustments; it’s advisable for these individuals to work closely with healthcare providers to tailor their treatment. Regular follow-ups can lead to optimal management of therapy while minimizing adverse effects.

Buying Guide

When looking to buy Uniphyl in Canada, local pharmacy sources like Shoppers, Rexall, Jean Coutu, and London Drugs are your go-to options. These retail chains typically stock this medication, but availability can vary based on your location.

Tips for Checking Availability:

• Call ahead to confirm stock in urban settings, where demand is usually higher.
• For rural areas, consider checking online or ordering in advance to ensure your prescription is filled on time.

Pricing can also differ significantly between in-store and online purchases. Check out popular pharmacy websites for competitive pricing or consider cross-border shopping to save on costs. Canadian prices for Uniphyl may at times be higher than in the US. It’s worth checking for:

• Promotional opportunities, especially during holiday seasons.
• Any potential discounts for loyalty program members.

What’s Inside & How It Works

Uniphyl CR primarily contains the active ingredient Theophylline, a bronchodilator used in the management of asthma and chronic obstructive pulmonary disease (COPD). Its presence helps patients understand the essence of their treatment.

How Theophylline Works:

Theophylline relaxes muscles in the airways, making breathing easier. It achieves this by blocking specific receptors that cause airway constriction. Essentially, it widens the air passages and reduces the symptoms associated with asthma and COPD, allowing for better airflow.

Main Indications

In Canada, Uniphyl CR is approved for managing symptoms of asthma and COPD. It is recognized by both Health Canada and the FDA for these indications. The guidelines recommend careful monitoring and dosages, often individualized based on the patient's health status and response to treatment.

Physicians sometimes use Uniphyl for off-label purposes, such as treating other respiratory conditions or as part of a combination therapy in complex cases. While these uses may not be formally approved, they can be significant in comprehensive patient management when other treatments do not suffice.

Interaction Warnings

Avoiding certain food interactions is crucial when taking Uniphyl. Common dietary items like alcohol and caffeine can have significant implications. Excessive caffeine may enhance side effects such as restlessness or elevated heart rate, while alcohol can intensify adverse effects.

Regarding drug interactions, it’s essential to refer to the Health Canada database for an updated list of potential conflicts. While many medications may interact with Uniphyl, ones such as macrolide antibiotics and fluoroquinolones are particularly noteworthy. Always consult healthcare providers for a full list and personalized advice.

Latest Evidence & Insights

Canadian and international research continues to shed light on the efficacy and safety of Uniphyl CR (theophylline). Recent studies indicate that it remains an essential component in managing chronic asthma and COPD, particularly for patients who have not responded adequately to inhaled medications. Research highlights include:

• A study published in the Canadian Journal of Respiratory Therapy demonstrated improved lung function in patients using Uniphyl CR compared to placebo.
• International research indicated that therapeutic drug monitoring significantly reduces the risk of toxicity associated with theophylline use.

Key insights and conclusions from the latest reports are summarized in the table below:

Alternative Choices

When considering alternatives to Uniphyl CR, several options exist such as beta-agonists and inhaled corticosteroids. Each alternative has its pros and cons.

Regulation Snapshot

In Canada, the approval of Uniphyl CR by Health Canada underscores its significance as a prescription medication. A crucial aspect of this regulation is the Drug Identification Number (DIN), which ensures that each medication is identifiable and safe for use.

The regulation of prescription medications involves stringent assessments to verify efficacy and safety before they reach the market, providing assurance to both healthcare professionals and patients.

FAQ Section

1. What is Uniphyl used for?

Uniphyl is primarily used for the maintenance treatment of chronic asthma and COPD.

2. How should Uniphyl be taken?

It is generally taken as an extended-release tablet, typically once daily, as prescribed by a healthcare provider.

3. Are there any side effects?

Common side effects include nausea, headaches, and restlessness; however, serious side effects require immediate medical attention.

4. Can I adjust my dose on my own?

No, it's essential to consult with a healthcare professional before making any changes to the dosage.

Guidelines for Proper Use

To ensure safe and effective use of Uniphyl CR, recommendations from Canadian pharmacists and provincial health authorities include:

• Regular monitoring of serum theophylline levels to avoid toxicity.
• Consulting healthcare professionals before making any adjustments to therapy.
• Being aware of potential drug interactions, particularly with antibiotics and certain medications.

These guidelines help in managing side effects and ensuring treatment efficacy.

Delivery Information